FIGURE

Fig. 1

ID

ZDB-FIG-221203-5

Publication

Sander et al., 2021 - Approved drugs ezetimibe and disulfiram enhance mitochondrial Ca²⁺ uptake and suppress cardiac arrhythmogenesis

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Fig. 1

Identification of novel MiCUps by chemical screening. (a) Example of Ca²⁺-dependent, mitochondrial aequorin kinetics in digitonin-permeabilized HeLa cells upon the addition of 4-μM free Ca²⁺ (black arrow) in the presence of candidate drugs (10 μM), experimental (10-μM Ru360) and vehicle controls (0.1% [v/v] DMSO). (b) Ranking of compounds based on S_drug scores. (c) Representative traces of averaged mitochondrial Ca²⁺ kinetics and quantification of mitochondrial (mt)-Ca²⁺ uptake rate in mitochondria of permeabilized HeLa cells treated with different concentrations of honokiol, cefatrizine, ezetimibe and disulfiram and 0.1% (v/v) DMSO (vehicle; Veh.) (n = 4)

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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