FIGURE

Figure 7—figure supplement 1.

ID

ZDB-FIG-221118-199

Publication

Ding et al., 2022 - A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene

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Figure 7—figure supplement 1.

RNA sequencing identifies transcriptome changes in the Dnajb6^+/- mice atrium.

(A) Principal component analysis (PCA) reveals the variance in transcriptome distribution in the Dnajb6^+/- mice and WT controls at 6 months. Each point represents the projections of individual hearts onto principal component (PC). (B) Heatmap of genes differentially expressed in the Dnajb6^+/- mice and WT controls. Each column represents an individual replicate and there are 3 replicates per group. Each row represents an individual gene. The color bar represents relative expression of log-transformed, normalized counts with upregulated genes shown in red and downregulated genes in blue. (C) Volcano plot shows magnitude and significance of genes that altered in distribution in the Dnajb6^+/- mice and WT controls. Genes that significantly downregulated in the Dnajb6^+/- mice are plotted in blue (left) and upregulated are plotted in red (right). (D) Ingenuity Pathway Analysis (IPA) of differentially expressed genes in the Dnajb6^+/- mice and WT controls. Signaling pathways are organized in the order of significance as –log10 of P value.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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