FIGURE

Figure 5—figure supplement 1.

ID

ZDB-FIG-221118-195

Publication

Ding et al., 2022 - A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene

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Figure 5—figure supplement 1.

Sinus node recovery time was prolonged in the Dnajb6^+/- mice.

(A–B) Representative activation maps reconstructed for the last pacing stimulus (S1) and the first spontaneous post-pacing atrial beat (A1) during SAN recovery time (SANRT) measurements are shown. A site of the earliest atrial activation is labeled by a white asterisk. In Dnajb6^+/- group, unlike WT, the first spontaneous post-pacing atrial beat (A1) originated from an ectopic location outside of the anatomically and functionally defined SAN area. (C) Summarized data for corrected SANRT (+/-) measured during different autonomic stimulations is shown. N=7–9 mice per group, unpaired student’s t-test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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