FIGURE

Figure 10

ID

ZDB-FIG-220921-37

Publication

Li et al., 2022 - Cd248a and Cd248b in zebrafish participate in innate immune responses

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Figure 10

Effect of cd248 deletion on inflammatory cytokines. The mutants of cd248a and cd248b were carried out by CRISPR/Cas9 system. (A–C) CRISPR/Cas9 gRNA design and the genotyping result of the cd248a-mutant allele; (D–F) CRISPR/Cas9 gRNA design and the genotyping result of the cd248b-mutant allele; (G, H) Quantitative analysis of the expression of cd248a or cd248b after cd248a-deletion or cd248b-deletion compared with WT respectively; (I) Quantitative analysis of the expression of zebrafish tnfα, il1β and il6 in the cd248-mutants and LPS treatment. (J) Quantitative analysis of the expression of il4 in the cd248-mutants compared with WT. Data were shown as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. ns, not significant.

Expression Data

Genes:	cd248a cd248b il1b il4 il6 tnfa
Fish:	AB cd248a^{ouc301/ouc301} (AB) cd248b^{ouc302/ouc302} (AB)
Condition:	chemical treatment by injection: lipopolysaccharide
Anatomical Term:	whole organism
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cd248a^{ouc301/ouc301} (AB) cd248b^{ouc302/ouc302} (AB)
Condition:	chemical treatment by injection: lipopolysaccharide
Observed In:	whole organism
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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