ZFIN Image: Li et al., 2022, Figure 10

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Figure Caption

Figure 10

Effect of cd248 deletion on inflammatory cytokines. The mutants of cd248a and cd248b were carried out by CRISPR/Cas9 system. (A–C) CRISPR/Cas9 gRNA design and the genotyping result of the cd248a-mutant allele; (D–F) CRISPR/Cas9 gRNA design and the genotyping result of the cd248b-mutant allele; (G, H) Quantitative analysis of the expression of cd248a or cd248b after cd248a-deletion or cd248b-deletion compared with WT respectively; (I) Quantitative analysis of the expression of zebrafish tnfα, il1β and il6 in the cd248-mutants and LPS treatment. (J) Quantitative analysis of the expression of il4 in the cd248-mutants compared with WT. Data were shown as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. ns, not significant.

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Acknowledgments

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