FIGURE

Fig. 6

ID

ZDB-FIG-220829-72

Publication

Da'as et al., 2022 - Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

The adult zebrafish mybpc3 mutant heart anatomy and histology. Adult age-matched zebrafish hearts were dissected (location: red star) and then compared across groups: (A) Control, (B) Heterozygous mybpc3+/−, and (C) Homozygous mybpc3−/− mutant. (i). Representation of the anatomical position of the heart in the adult zebrafish. (ii). The dissected heart demonstrates the two cardiac chambers, a single atrium (A), and a single ventricle (V), with an elastic, non-contractile chamber consisting of smooth muscle bulbus arteriosus (BA). (iii). Histological organization of the adult zebrafish ventricle, magnification 80×, scale bar: 10 μm. (iv). The ventricular myocardial wall is hypertrophic in the zebrafish mybpc3 mutant model (red square) when compared to the control group subset, magnification 150×, scale bar: 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mybpc3^dsme1/+; zf3671Tg mybpc3^dsme1/dsme1; zf3671Tg
Observed In:	cardiac ventricle heart myocardium
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.