FIGURE

Fig. 6

ID

ZDB-FIG-220630-46

Publication

Cai et al., 2022 - Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Figure 6. Otud3-deficient mice are susceptible to HSV infection (A) Survival (Kaplan-Meier curve) of Otud3+/+ and Otud3−/− mice (n = 6 per group) at various time after i.p. injection with HSV (1 × 107 PFU per mouse). (B) ELISA of IFN-β in serum from Otud3+/+ and Otud3−/− mice (n = 6) given i.p. injection of HSV-1 (1 × 107 PFU per mouse) for 24 h. (C) Microscopy of H&E-stained lung sections from Otud3+/+ and Otud3−/− mice treated with PBS (mock) or HSV-1 (1 × 107 PFU per mouse) for 48 h. Scale bar, 300 μm. (D and E) qRT-PCR analysis of Ifn-b, Isg56, Cxcl10, and Il6 in the lungs (D, n = 6) and spleen (E, n = 6) from Otud3+/+ and Otud3−/− mice given i.p. injection of HSV-1 (1 × 107 PFU per mouse) for 48 h. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001, using unpaired Student’s t test (B, D, and E) or log rank (Mantel-Cox) test (A). Data based on one representative experiment performed in three biological replicates from at least three independent experiments (mean ± SD) or representative data (C).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Rep.