FIGURE

Fig. 4

ID

ZDB-FIG-220617-48

Publication

Tuschl et al., 2022 - Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafish

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Fig. 4

MnCl₂ treatment alters neuronal activity in both wild-type and slc39a14^−/− larvae. (A-D) Z-projection of cfos mRNA expression in the brain of wild-type (A) and homozygous mutant larvae (C) at 6 dpf following treatment with 50 µM MnCl₂ from 2 dpf. B and D list the brain regions with enhanced (magenta) and suppressed (green) neuronal activity by genotype. A, anterior; P, posterior; D, dorsal; V, ventral; L, lateral; M, medial. Scale bars: 100 µm.

Expression Data

Gene:	fosab
Fish:	WT slc39a14^u801/u801
Condition:	chemical treatment by environment: manganese(II) chloride
Anatomical Terms:	caudal hypothalamic zone central zone of the optic tectum corpus cerebelli dorsal telencephalon granular eminence hypothalamus medulla oblongata nucleus of the medial longitudinal fasciculus synencephalon olfactory bulb optic tectum posterior lateral line ganglion postoptic commissure preoptic area pretectum tangential nucleus tegmentum thalamus torus semicircularis vagal ganglion ventral telencephalon vestibulospinal neuron whole organism
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT slc39a14^u801/u801
Condition:	chemical treatment by environment: manganese(II) chloride
Observed In:	caudal hypothalamic zone central zone of the optic tectum corpus cerebelli dorsal telencephalon granular eminence hypothalamus medulla oblongata nucleus of the medial longitudinal fasciculus synencephalon olfactory bulb optic tectum posterior lateral line ganglion postoptic commissure preoptic area pretectum tangential nucleus tegmentum torus semicircularis vagal ganglion ventral telencephalon vestibulospinal neuron
Stage:	Day 6

Phenotype Detail

Acknowledgments

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