FIGURE

Fig. 5

ID

ZDB-FIG-220513-34

Publication

Hortle et al., 2022 - OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Figure 5. Infection-induced OXSR1 suppresses inflammasome activity to aid mycobacterial infection.

(A) Representative images of Tg(tnfa:GFP)^pd1028 fluorescence around M. marinum granulomas. Scale bar represents 200 μM. (B) Quantification of TNF-α fluorescence per bacterial area in WT embryos treated with Compound B. (C) Quantification of TNF-α fluorescence per bacterial area in WT, mosaic F0 oxsr1a, Il1b, and dual oxsr1a Il1b crispant embryos. Combined results of two independent experiments. (D) Quantification of TNF-α fluorescence per bacterial area in WT, mosaic F0 oxsr1a, tnfa, and dual oxsr1a tnfa crispant embryos. Combined results of two independent experiments. (E) Quantification of bacterial burden in WT, mosaic F0 oxsr1a, tnfa, and dual oxsr1a tnfa crispant embryos. Combined results of two independent experiments. Fish were infected with WT M. marinum by caudal vein injection at 30 h post fertilization and analysed 5 dpi.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Life Sci Alliance