FIGURE
Fig. 2
- ID
- ZDB-FIG-220513-31
- Publication
- Hortle et al., 2022 - OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection
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Fig. 2
Figure 2. ∆ESX1-M. marinum does not induce OXSR1 gene expression.
(A) Relative expression of oxsr1a and stk39 in zebrafish embryos at 3 days post infection with ∆ESX1–M. marinum compared with age-matched uninfected controls. Biological replicates (n = 4) represent pooled RNA from 7 to 10 embryos. (B) Quantification of ∆ESX1–M. marinum bacterial burden in WT and mosaic F0 oxsr1a CRISPR embryos. (C) Quantification of ∆ESX1–M. marinum bacterial burden in WT, heterozygous and homozygous oxsr1a knockout embryos. (D) Quantification of ∆ESX1–M. marinum bacterial burden in DMSO vehicle control and Compound B–treated embryos at 1.8 μM. |
Expression Data
| Genes: | |
|---|---|
| Fish: | |
| Condition: | |
| Anatomical Term: | |
| Stage: | Protruding-mouth |
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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