FIGURE

Figure 5

ID

ZDB-FIG-220430-148

Publication

Wu et al., 2022 - Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish

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Figure 5

Figure 5. Biosynthesis of amino acids and aminoacyl-tRNA were enhanced in slc38a9^−/− embryos. (A) Heatmaps of transcripts in the biosynthesis of amino acids’ enrichment. (B) Heatmaps of transcripts in aminoacyl-tRNA synthetases’ enrichment. (C) Most free amino acids (FAAs) increased in slc38a9^−/− mutants. The contents of most FAAs (Leu, Met, Ile, Val, Lys, etc.) increased except for Pro, Glu, and Asp. The profile of FAAs was measured using the automated amino acid analyzer. (D) The relative FPKM of major aminotransferases in WT and slc38a9 mutant zebrafish embryos (60 hpf). Data shown are mean ± SEM, n = 3. * p < 0.05, ** p < 0.01, *** p < 0.005.

Expression Data

Genes:	glud1a glud1b got1 got1l1 got2a got2b gpt2
Fish:	WT slc38a9^{ouc101/ouc101} slc38a9^{ouc102/ouc102}
Anatomical Term:	whole organism
Stage:	Pec-fin

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	slc38a9^{ouc101/ouc101}
Observed In:	whole organism whole organism alanine whole organism aspartic acid whole organism glutamic acid whole organism glycine whole organism histidine whole organism isoleucine whole organism leucine whole organism lysine whole organism methionine whole organism phenylalanine whole organism proline whole organism serine whole organism threonine whole organism tyrosine whole organism valine
Stage:	Pec-fin

Phenotype Detail

Acknowledgments

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