FIGURE

Fig 5

ID

ZDB-FIG-220426-31

Publication

Gibson et al., 2022 - Blood vessel occlusion by Cryptococcus neoformans is a mechanism for haemorrhagic dissemination of infection

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Fig 5

Cryptococcal cell size influences the frequency of trapping within blood vessels.

A-E: Infection of KDRL mCherry blood marker transgenic line with 1000 cfu Δplb1-H99, Δlac1-H99 or parental H99-GFP C. neoformans A Size of cryptococcal cells injected into zebrafish larvae on the day of infection (>300 cryptococcal cells measured per strain) B Blocked vessels (% of all inter-segmental vessels) at 1 dpi (n = 2, +/- SD, **p<0.01, Kruskal-Wallis test) C Blocked vessels (% of all inter-segmental vessels) at 3 dpi (n = 2, +/- SD, Kruskal-Wallis test) D Vessel width with or without C. neoformans at 1 dpi (n = 2, +/- SD, ns = not significant, **p<0.01, ****p<0.0001, Kruskal-Wallis test) E Vessel width with or without C. neoformans at 3 dpi (n = 2, +/- SD, ns = not significant, *p<0.05, ****p<0.0001, Kruskal-Wallis test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s916Tg/s916Tg
Condition:	biological treatment: Cryptococcus neoformans
Observed In:	intersegmental vessel intersegmental vessel formation of infection structure intersegmental vessel vascular transport
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

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