FIGURE

Figure 4

ID

ZDB-FIG-220422-12

Publication

Boddy et al., 2022 - Unbiased metabolome screen leads to personalized medicine strategy for amyotrophic lateral sclerosis

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Figure 4

Application of estradiol to a zebrafish model of C9ORF72-ALS reduces cellular stress. (A) The effect of 3 days of metabolic supplementation on zebrafish DsRed expression with 10µM estradiol (30.4% reduction in DsRed expression, Kruskal Wallis H-test with Dunn’s multiple testing correction P = 0.0003), 30 mM inosine (26.1% reduction, P = 0.0024) or 10 µM riluzole (43.9% reduction, P < 0.0001). (B) The effect of metabolic supplementation on zebrafish GFP expression; no significant changes were observed. Untreated Tg indicates transgenic fish treated with 0.1% DMSO vehicle control. NTg indicates non-transgenic fish. Data presented as mean with standard deviation from two independent clutches of fish. ** P≤0.01. ****P≤0.001.

Expression Data

Gene:	DsRed
Fish:	sh578Tg (AB)
Conditions:	chemical treatment by environment: estradiol chemical treatment by environment: inosine chemical treatment by environment: Riluzole
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sh578Tg (AB)
Conditions:	chemical treatment by environment: estradiol chemical treatment by environment: inosine chemical treatment by environment: Riluzole
Observed In:	whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

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