ZFIN Image: Boddy et al., 2022, Figure 4

Image

Figure Caption

Figure 4

Application of estradiol to a zebrafish model of C9ORF72-ALS reduces cellular stress. (A) The effect of 3 days of metabolic supplementation on zebrafish DsRed expression with 10µM estradiol (30.4% reduction in DsRed expression, Kruskal Wallis H-test with Dunn’s multiple testing correction P = 0.0003), 30 mM inosine (26.1% reduction, P = 0.0024) or 10 µM riluzole (43.9% reduction, P < 0.0001). (B) The effect of metabolic supplementation on zebrafish GFP expression; no significant changes were observed. Untreated Tg indicates transgenic fish treated with 0.1% DMSO vehicle control. NTg indicates non-transgenic fish. Data presented as mean with standard deviation from two independent clutches of fish. ** P≤0.01. ****P≤0.001.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Brain Commun