FIGURE

Fig 5

ID

ZDB-FIG-220307-5

Publication

Habicher et al., 2022 - Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development

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Fig 5

Craniofacial malformations in csgalnact1a^-/- and csgalnact1a^-/-; csgalnact2^-/- larvae.

LightSheet images of live Tg(col2a1a:mEGFP) larvae at 6 dpf show craniofacial cartilage elements formed in csgalnact1a^+/+;csgalnact2^+/- (A,B,C), csgalnact1a^-/-;csgalnact2^+/- (D,E,F) and csgalnact1a^-/-;csgalnact2^-/- larvae (G,H,I). Lateral views (A,D,G) display a shorter ceratohyal, ventral views display a wider angle between the ceratohyal elements in csgalnact1a^-/-;csgalnact2^+/- (E) and csgalnact1a^-/-;csgalnact2^-/- (G) larvae (arrow) compared to controls (A,B). A detailed view on the chondorcytes within the ceratohyal (arrow) shows that intercalation occurs even in csgalnact1a^-/- (F) and csgalnact1a^-/-;csgalnact2^-/- (I) larvae.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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