FIGURE

Fig. 9

ID

ZDB-FIG-220224-24

Publication

Jin et al., 2021 - An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function

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Fig. 9

Mitochondrial defects in the zebrafish retina. A and B, assessment of mitochondrial function in the retina by enzyme histochemistry (EHC) staining for COX (A) and SDH (B) in the frozen sections of retina in the yars2+/+, yars2+/?, and yars2?/? larvae at 5 dpf. Scale bar, 100 ?m. C and D, mitochondrial morphology from photoreceptors (PR) (C) and RGC (D) of transmission electron microscopy. Ultrathin sections were visualized with 25,000� magnification. Scale bar, 1 ?m. e, ellipsoid; m, mitochondrion; n, nucleus; os, outer segment of photoreceptors. E and F, quantification of mitochondrial numbers of photoreceptors (E) from yars2+/+ (n = 20), yars2+/? (n = 20), and yars2?/? (n = 25) and RGC (F) from yars2+/+ (n = 32), yars2+/? (n = 24), and yars2?/? (n = 25) zebrafish at 5dpf. Graph details and symbols are explained in the legend to Figure 2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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