FIGURE

Figure 1

ID

ZDB-FIG-220131-163

Publication

Han et al., 2021 - Precise Dose of Folic Acid Supplementation Is Essential for Embryonic Heart Development in Zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Figure 1

Zebrafish heart dysplasia caused by folic acid and folic acid inhibitors is dose-dependent. (A) The use of different concentrations of folic acid inhibitors can cause abnormal heart development in zebrafish embryos. The concentration of MTX1.5 mM will cause the zebrafish embryo to be deformed and unable to break the eggs. Arrowheads mark abnormal heart development. Arrows indicate trunk flexion. Scale bars: 500 μm. (B) Excessive folic acid can also cause abnormal heart development in zebrafish embryos. Scale bars: 500 μm. (C) The heart rate of zebrafish embryos treated with folic acid inhibitors was statistically analyzed. (D) The ventricular diastolic volume of zebrafish embryos treated with folic acid inhibitors was statistically analyzed. (E) The heart rate of zebrafish embryos treated with different concentrations of folic acid was analyzed statistically. (F) The ventricular diastolic volume of zebrafish embryos treated with different concentrations of folic acid was statistically analyzed. (Student t-test, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns: no statistical difference).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biology (Basel)