ZFIN Image: Han et al., 2021, Figure 1

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Figure 1

Zebrafish heart dysplasia caused by folic acid and folic acid inhibitors is dose-dependent. (A) The use of different concentrations of folic acid inhibitors can cause abnormal heart development in zebrafish embryos. The concentration of MTX1.5 mM will cause the zebrafish embryo to be deformed and unable to break the eggs. Arrowheads mark abnormal heart development. Arrows indicate trunk flexion. Scale bars: 500 μm. (B) Excessive folic acid can also cause abnormal heart development in zebrafish embryos. Scale bars: 500 μm. (C) The heart rate of zebrafish embryos treated with folic acid inhibitors was statistically analyzed. (D) The ventricular diastolic volume of zebrafish embryos treated with folic acid inhibitors was statistically analyzed. (E) The heart rate of zebrafish embryos treated with different concentrations of folic acid was analyzed statistically. (F) The ventricular diastolic volume of zebrafish embryos treated with different concentrations of folic acid was statistically analyzed. (Student t-test, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns: no statistical difference).

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