FIGURE

Figure 1

ID

ZDB-FIG-211201-143

Publication

Joshi et al., 2021 - Zebrafish Model to Study Angiotensin II-Mediated Pathophysiology

Other Figures

All Figure Page

Back to All Figure Page

Figure 1

Intradermal Angiotensin II injection induces cardiac hypertrophy in adult zebrafish. (A,B) Diagrams showing experimental procedure (A) and site of intradermal injection (B). (C) Survival assay assessed the viability of the PBS or AngII injected animals at different time points (n = 18 each from 3 independent experiments). Error bars indicate the mean ± s.d. (D) Images of PBS or AngII injected zebrafish at 7 dpi. (E) Bright-field images of cardiac ventricles isolated from PBS or AngII injected animals at 7 dpi. Arrowheads indicate the atrioventricular canal. Scale bars, 200 µm. (F) Statistical analysis of the ratio of the 2D surface area of the ventricle and body length of individual fish at 7 dpi (n = 5 each from 2 independent experiments). (G) Quantitative analysis of weight loss in 14 PBS injected and 14 AngII injected zebrafish from 3 independent experiments. (H) Quantitative analysis of the expression of igf1 in cardiac ventricles from PBS or AngII injected animals at 7 dpi (n = 3, each sample represents a pool of 6 hearts). Error bars indicate the mean ± s.e.m. dpi: days post-injection; OFT, outflow tract. Significant, p < 0.05; non-significant, p ≥ 0.05.

Expression Data

Gene:	igf1
Fish:	AB
Condition:	chemical treatment by injection: angiotensin II
Anatomical Term:	cardiac ventricle
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	chemical treatment by injection: angiotensin II
Observed In:	cardiac ventricle whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biology (Basel)