FIGURE

Fig 8

ID

ZDB-FIG-211122-30

Publication

Kikel-Coury et al., 2021 - Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function

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Fig 8

CNG regulate heart rate and rhythm.

(A) Quantification of the number of ventricular contractions (bpm) at 6 dpf after various gfap⁺ ablation techniques. (B) Quantification of percent duration of ventricular fibrillation in metrn^−/− animals and Tg(gfap:nucGFP) animals with full laser ablation of nucGFP⁺ cells. (C) Representative graphs of ventricular blood flow intensity (au) over time in wild-type animals. (D) Representative graphs of ventricular blood flow intensity (au) over time in metrn^+/− animals. (E) Representative graphs of ventricular blood flow intensity (au) over time in metrn^−/− animals. (F) Schematic of gfap⁺ ablation by location. Green dots denote gfap⁺ cells. Lightning denotes ablation. (G) Quantification of number of ventricular contractions at 6 dpf after ablation of gfap⁺ by location. Data are represented as mean ± SEM. Statistics summarized in S1 Table. See S1 Data for raw data. A, atrium; bpm, beats per minute; CNG, cardiac nexus glia; dpf, days postfertilization; MTZ, metronidazole; OT, outflow tract; V, ventricle.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	metrn^nt200/+; mi2004Tg metrn^nt200/nt200; mi2004Tg
Observed In:	cardiac ventricle heart contraction heart contraction
Stage:	Day 6

Phenotype Detail

Acknowledgments

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