FIGURE

Figure 2

ID

ZDB-FIG-211120-54

Publication

Rodríguez-Ortiz et al., 2021 - Mutants of the Zebrafish K⁺ Channel Hcn2b Exhibit Epileptic-like Behaviors

Other Figures

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Figure 2

Characterization of the hcn2b^−/− mutant. (A) Compared morphology between WT and hcn2b^−/− zebrafish mutant at 48 h post-fertilization (hpf): there are no differences in length and pigmentation. (B) Homozygous hcn2b mutants showed a higher mortality rate than controls (4–16% vs. 60–80%). (C) No evident defects were detected during early heart development. Both heart morphology and volume were similar in WT and hcn2b^−/− (D). Heart rate showed statistically significant differences between WT and hcn2b^−/− larvae at 48- and 56-h post-fertilization. Asterisk indicate statistical significance compared to the control, p < 0.05 (*); p < 0.005 (**).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hcn2b^{una101/una101}
Observed In:	heart contraction integument whole organism
Stage Range:	Prim-25 to Days 45-89

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.