FIGURE

FIGURE 4

ID

ZDB-FIG-211029-68

Publication

Zhang et al., 2021 - The Ribosome Biogenesis Factor Ltv1 Is Essential for Digestive Organ Development and Definitive Hematopoiesis in Zebrafish

Other Figures

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FIGURE 4

Figure 4. Impaired proliferation of exocrine pancreas progenitors and HSPCs in ltv1^Δ14/Δ14 mutant. (A,B) Representative confocal images of pH3 immunostaining (A) or BrdU labeling (B) in ltv1^Δ14/Δ14; ptf1a:gfp mutants and siblings at 2 dpf. (A’,B’) The percentage of pH3⁺ (A’, siblings, N = 6; mutants, N = 9) or BrdU⁺ (B’, siblings, N = 6; mutants, N = 6) cells within the ptf1a⁺ population in ltv1^Δ14/Δ14 mutants and siblings at 2 dpf. Bars represent means with SD. (C,D) Representative confocal images of pH3 immunostaining (C) and BrdU labeling (D) in ltv1^Δ14/Δ14; runx1:en-gfp mutants and siblings at 2.5 dpf. (C’,D’) The percentage of pH3⁺ (C’, siblings, N = 6; mutants, N = 7) and BrdU⁺ (D’, siblings, N = 6; mutants, N = 11) cells within the runx1⁺ population in ltv1^Δ14/Δ14 mutants and siblings at 2.5 dpf. Bars represent means with SD. White arrow: merged cell. Scale bar: 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ltv1^swu54/swu54; ioz1Tg (TU) ltv1^swu54/swu54; jh1Tg (TU)
Observed In:	caudal hematopoietic tissue cell population proliferation exocrine pancreas cell population proliferation hematopoietic multipotent progenitor cell cell population proliferation hematopoietic stem cell cell population proliferation
Stage Range:	Long-pec to Pec-fin

Phenotype Detail

Acknowledgments

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