FIGURE

Fig 4

ID

ZDB-FIG-210912-4

Publication

Minenkova et al., 2021 - Is impaired energy production a novel insight into the pathogenesis of pyridoxine-dependent epilepsy due to biallelic variants in ALDH7A1?

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Fig 4

A & B. Scatterplot of quantification of the TCA cycle metabolite levels.

TCA cycle metabolite levels are reduced in aldh7a1 knock-out zebrafish embryos. Scatterplot of quantification of the TCA cycle metabolite levels decreased in aldh7a1 11 dpf knock-out embryos (aldh7a1 knock-out, grey squares) relative to the wildtype age-matched controls (Wildtype, black circles), as measured by LC-MS/MS. Each dot represents metabolite data collected from 20 embryos. p values were calculated by unpaired student t-test for multiple measurements followed by Holm-Sadak correction for multiple analysis. Error bars, SD.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aldh7a1^{zf2074/zf2074}
Observed In:	whole organism citrate(3-) whole organism fumarate(2-) whole organism isocitrate(3-) whole organism lactate whole organism malate whole organism succinate
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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