FIGURE

Figure 1

ID

ZDB-FIG-210902-263

Publication

Park et al., 2021 - Long-Chain Acyl-Carnitines Interfere with Mitochondrial ATP Production Leading to Cardiac Dysfunction in Zebrafish

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Figure 1

Carnitine shuttle in mitochondria and chemical structures of carnitines. (A) Description of acylcarnitine metabolism (free fatty acid metabolism) in general. Acyl-CoA and carnitine are conjugated (acylcarnitine) by carnitine-palmitoyl transferase I (CPT I) and transported across the inner membrane of mitochondria via carnitine-acylcarnitine translocase (CACT). Then, acyl-CoA and carnitine are released into the mitochondrial matrix by carnitine-palmitoyl transferase 2 (CPT II). Acyl-CoA is finally degraded and released as acetyl-CoA to enter the TCA cycle, synthesizing ATP. Subfigure A is created by BioRender.com (accessed on 23 March, 2021). (B–E) Molecular structures of acyl-l-carnitine, short-chain carnitine and long-chain acylcarnitines (LCACs).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.