FIGURE

Fig 6

ID

ZDB-FIG-210623-61

Publication

Swartz et al., 2021 - Variation in phenotypes from a Bmp-Gata3 genetic pathway is modulated by Shh signaling

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Fig 6

Bmp signaling to maxillary neural crest regulates the expression of <italic toggle='yes'>gata3</italic>.

(A-D) Lateral views with anterior to the left of 36 hpf gata3 in situ hybridization black arrows point to maxillary crest that will give rise to trabeculae; white arrows mark the ear. (A-B) Embryos from a smad5 clutch. (A) Wild type embryo showing strong expression of gata3 in maxillary trabeculae precursors. (B) Mutant embryo showing loss of gata3 expression in trabeculae precursors. (C-D) Embryos from a hsp:DN-Bmpr1a clutch. (C) No heat shock embryo arrowhead indicates gata3 expression in maxillary precursors. (D) Embryo heat shocked at 24 hpf arrowhead indicates loss of gata3 expression in maxillary CNCC. (E-G) Confocal images of Bmp responsive cells (green, cytoplasmic) and CNCC (red, membrane tagged), lateral views with anterior to the left at 24 hpf. Arrow points to Bmp responsive maxillary neural crest cells.

Expression Data

Gene:	gata3
Fish:	smad5^b1100/b1100 w30Tg/w30Tg
Condition:	heat shock
Anatomical Term:	neurocranium neural crest cell
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	smad5^b1100/b1100 w30Tg/w30Tg mw30Tg/mw30Tg; vu234Tg/vu234Tg
Condition:	heat shock
Observed In:	cranial neural crest BMP signaling pathway neurocranium neural crest cell
Stage Range:	Prim-5 to Prim-25

Phenotype Detail

Acknowledgments

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