FIGURE

Figure 2

ID

ZDB-FIG-210606-161

Publication

Rohrer et al., 2021 - Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function

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Figure 2

Immunohistochemical analysis of rod and cone photoreceptors in wild-type and exoc5−/− mutant zebrafish. Rod photoreceptor outer segments were identified with ZPR3 antibody (green, ZPR3, (A)), cone photoreceptors with PNA-lectin-488 (green, PNA, (B)), and medium-wavelength R/G cone opsins (red, R/G Opsin, (C)), all at 3.5 dpf. Loss of rod and cone OS immunofluorescence was noted in exoc5−/− mutant zebrafish. Scale bars = 50 μm (B) and 25 μm (A,C). OS, outer segments; ONL, outer nuclear layer; INL, inner nuclear layer. (A’–C’) Image J was used to quantify immunofluorescence for the 3 OS markers. ** p < 0.005 (WT vs. exoc5−/− mutants).

Expression Data

Antibody:	zpr-3
Fish:	AB/TU exoc5^{sa23168/sa23168} (AB/TU)
Anatomical Term:	retinal rod cell rod photoreceptor outer segment
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	exoc5^{sa23168/sa23168} (AB/TU)
Observed In:	retinal cone cell cone photoreceptor outer segment retinal cone cell photoreceptor cell outer segment organization retinal rod cell photoreceptor cell outer segment organization retinal rod cell rod photoreceptor outer segment
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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