FIGURE

Figure 5

ID

ZDB-FIG-210519-78

Publication

Knickmeyer et al., 2021 - BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish

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Figure 5

pax2a expression domains are differentially altered in bmp4 induction and Shh inhibition conditions. (A–J) In situ hybridization of pax2a. (A–D) 21 hpf in (A) control and (B) tg(hsp70l:bmp4) embryos after heat shock at 15 hpf; (C) ethanol control and (D) Cyclopamine-treated embryos. (E–J) 42 hpf in (E) control and (F) tg(hsp70l:bmp4) embryos after heat shock at 15 hpf. Part of the pax2a domain extends dorsally (arrows). (G) Ethanol control and (H–J) Cyclopamine-treated embryos with different expression patterns (n = 12); (E’–J’) show a more anterior region in the same embryos as (E–J). All images are maximum intensity projections, DAPI counterstaining, transverse view, scale bars 50 µm.

Expression Data

Gene:	pax2a
Fish:	WT af1Tg
Conditions:	chemical treatment by environment: Cyclopamine heat shock
Anatomical Terms:	diencephalon ventral region optic stalk
Stage Range:	20-25 somites to High-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT af1Tg
Conditions:	chemical treatment by environment: Cyclopamine heat shock
Observed In:	diencephalon ventral region optic stalk
Stage:	High-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.