FIGURE

Figure 2

ID

ZDB-FIG-210503-14

Publication

Kamel et al., 2021 - A Heterozygous Mutation in Cardiac Troponin T Promotes Ca²⁺ Dysregulation and Adult Cardiomyopathy in Zebrafish

Other Figures

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Figure 2

Morphological changes in tnnt2a^+/RK94del observed during different stages of development. (A,B) Images of 5 dpf embryonic hearts for tnnt2a^+/+ and tnnt2a^+/RK94del. (C–H) H&E staining of heart sections of tnnt2a^+/+ and tnnt2a^+/RK94del at (C,D) 2 weeks post-fertilization, (E,F) 4 weeks post-fertilization, and (G,H) 7 weeks post-fertilization. (I–L) In situ hybridization on adult heart sections of tnnt2a^+/+a nd tnnt2a+/RK94del stained for (I,J) amhc, a marker of atrial cells, and (K,L) vmhcl, a marker for adult zebrafish ventricular cells. Images were taken at a magnification of 20×. Scale bars are 100 µm (A–F), 50 µm (G–I), and 200 µm for whole-heart tile scans (I–L) with 50 µm for zoom-in regions. A: atrium, V: ventricle, BA: bulbus arteriosus.

Expression Data

Genes:	myh6 myh7l
Fish:	WT tnnt2a^hu11320/+ (TL)
Anatomical Terms:	atrium cardiac ventricle
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tnnt2a^hu11320/+ (TL)
Observed In:	atrium atrium myocardium cardiac ventricle
Stage Range:	Day 5 to Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Cardiovasc Dev Dis