FIGURE

Fig. 6

ID

ZDB-FIG-210301-161

Publication

Ferrero et al., 2020 - A csf1rb mutation uncouples two waves of microglia development in zebrafish

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Fig. 6

Adult zebrafish csf1rb mutant display hematopoietic deficiencies. (A,B) Flow cytometry analysis of WKM cell suspensions from wild-type, csf1ra^−/− and csf1rb^−/− adult fish carrying the mpeg1:EGFP reporter. (A) The mpeg1:EGFPhi fractions identify mature macrophages (red frames), whereas the mpeg1:EGFP lo fractions contain mainly IgM-expressing B lymphocytes (blue frames) (Ferrero et al., 2020). (B) Percentage of mpeg1hi and mpeg1lo cells for each genotype, relative to the whole living WKM population. Each bar represents the mean±s.e.m. for three individuals. (C) Scatter profiles of WKM in typical wild-type (left panel), csf1ra^−/− (middle panel) and csf1rb^−/− (right panel) adult fish. (D) Percentage of cells in the lymphoid (black), myeloid (green) and progenitor (purple) fractions, relative to the whole hematopoietic cell population. Each bar represents the mean±s.e.m. for three individuals.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	csf1rb^re01/re01; gl22Tg; s898Tg; sd5Tg
Observed In:	caudal hematopoietic tissue macrophage
Stage:	Day 6

Phenotype Detail

Acknowledgments

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