FIGURE

Fig. 1

ID

ZDB-FIG-210228-7

Publication

Duan et al., 2021 - Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants

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Fig. 1

Identification of regulatory elements in tubular cells. a Schematic of strategy to functionally annotate disease-associated variants with 1D and 3D epigenetic landscapes. b ChromHMM-based chromatin states in tubular cells. Each row corresponds to a different state, and each column corresponds to a different mark for three histone modifications (H3K27ac, H3K4me3, H3K27me3). The blue color represents the probability for each mark in the state. c Proportion of the regions for each state in genome. d Segmentation state, H3K27ac, H3K4me3, H3K27me3 and RNA-seq tracks on chromosome 1 (225.82–225.92 Mb). Blue block highlights a novel promoter not defined by Refseq. e Segmentation state, H3K27ac, H3K4me3, H3K27me3, kidney H3K27ac and 7-cell type H3K27ac profiles on chromosome 16 (79.84–79.94 Mb). Blue blocks highlight enhancers including SUA2 and a novel enhancer. Kidney H3K27ac and 7-cell type H3K27ac profiles were from ENCODE

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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