ZFIN Image: Duan et al., 2021, Fig. 1

Image

Figure Caption

Fig. 1

Identification of regulatory elements in tubular cells. a Schematic of strategy to functionally annotate disease-associated variants with 1D and 3D epigenetic landscapes. b ChromHMM-based chromatin states in tubular cells. Each row corresponds to a different state, and each column corresponds to a different mark for three histone modifications (H3K27ac, H3K4me3, H3K27me3). The blue color represents the probability for each mark in the state. c Proportion of the regions for each state in genome. d Segmentation state, H3K27ac, H3K4me3, H3K27me3 and RNA-seq tracks on chromosome 1 (225.82–225.92 Mb). Blue block highlights a novel promoter not defined by Refseq. e Segmentation state, H3K27ac, H3K4me3, H3K27me3, kidney H3K27ac and 7-cell type H3K27ac profiles on chromosome 16 (79.84–79.94 Mb). Blue blocks highlight enhancers including SUA2 and a novel enhancer. Kidney H3K27ac and 7-cell type H3K27ac profiles were from ENCODE

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Biol.