FIGURE

Figure 2

ID

ZDB-FIG-210121-19

Publication

Lu et al., 2021 - Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish

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Figure 2

The spatial and temporal expression patterns of lpin1 during zebrafish early development. The expression of lpin1 mRNA was ubiquitous during cleavage and gastrula stages (A-C), restricted to paraxial mesoderm at the bud stage (D), and abundant at somites from the 8-somite stage onwards (E-H'). The dynamic lpin1 mRNA expression was detected in the retina (red arrows in F and F'), pectoral fins (pf, black arrows in G and G') and the cephalic musculature (cm, green arrows in G and G'). (I-J') IHC staining showed the Lpin1 protein expression in myotomes and the retina (yellow arrows), acetylated α-tubulin was stained in green color. (F-J) Lateral views of embryos, (F'- J') Dorsal views of embryos. Scale bar: 100 µm.

Expression Data

Gene:	lpin1a
Fish:	AB
Anatomical Terms:	cephalic musculature head myotome optic cup paraxial mesoderm pectoral fin retina somite whole organism
Stage Range:	1-cell to Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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