FIGURE

FIGURE 7

ID

ZDB-FIG-200829-92

Publication

Min et al., 2020 - Systems Analysis of Biliary Atresia Through Integration of High-Throughput Biological Data

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FIGURE 7

Activation of Hif1a signaling increases BEC number and impairs the proper formation of bile canaliculi. (A) Confocal projection images showing intrahepatic biliary network by Tp1:GFP expression in the liver (dotted lines) at 5 dpf. Boxed regions are enlarged. (B) Confocal projection images showing Tp1:H2B-mCherry expression (red; BEC nuclei) in the liver (dotted lines) at 5 dpf. Quantification of BEC number is shown. (C) Confocal projection images showing Abcb11 and Tp1:GFP expression in the liver (dotted lines) at 5 dpf. Arrowheads point to bile canaliculi. n indicates the number of larvae used for quantification. Scale bars: 50 μm; error bars: ± SD.

Expression Data

Genes:	EGFP mCherry
Fish:	s939Tg um14Tg
Anatomical Terms:	intrahepatic bile duct epithelial cell cytoplasm intrahepatic bile duct epithelial cell nucleus
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s939Tg um14Tg
Condition:	chemical treatment by environment: dimethyloxalylglycine
Observed In:	bile canaliculus intrahepatic bile duct epithelial cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Physiol.