FIGURE

Figure 6

ID

ZDB-FIG-200720-14

Publication

Amorim et al., 2020 - A Conserved Notochord Enhancer Controls Pancreas Development in Vertebrates

Other Figures

All Figure Page

Back to All Figure Page

Figure 6

Proper Pancreas Development Requires the Expression of Nog2 in the Notochord

(A) Diagram of the nog2 notochord enhancer driving expression of nog2. Nog2 diffusion from the notochord, located in the midline of the embryo, counteracts the signaling of Bmp2b from the lateral plate mesoderm, allowing the proper placement and proper size of the endocrine pancreas.

(B) When the activity of the nog2 notochord enhancer is disrupted, nog2 expression in the notochord is reduced. In this case, Bmp2b signaling is expanded, impairing β cell development and reducing pancreas size.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Rep.