FIGURE

Fig. 9

ID

ZDB-FIG-200413-40

Publication

Taler et al., 2019 - Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate

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Fig. 9

col4a5^s510 embryos show the same TGFβ-driven lens phenotype as plod3 mutants. (A,B) Live 4 dpf normal (A) and col4a5^s510/s510 (B) embryos. (n > 100 embryos). (C,D) Transverse histological sections of eyes from 3.5 dpf normal (C) and col4a5^s510/s510 (D) embryos. (n = 10 eyes from each genotype). (E,F) Live 4 dpf normal (E) (n = 6) and col4a5^s510/s510 (F) (n = 5) embryos, treated with SB-431542 from 30 hpf. (G,H) Transverse histological sections from eyes of the same normal and mutant embryos in G and H, respectively. Numbers of eyes analyzed: G = 12, H = 9. A,B,E,F are dorsal views, anterior to left, arrows point at lenses. Scale bars in A,B,E,F are 100 μm and in C,D,G,H 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT col4a5^s510/s510
Condition:	chemical treatment by environment: SB 431542
Observed In:	inner ear lens lens epithelium whole organism
Stage:	Day 4

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 458(2), Taler, K., Weiss, O., Rotem, S., Rubinstein, A.M., Seritrakul, P., Gross, J.M., Inbal, A., Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate, 177-188, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.