FIGURE

Fig. 2

ID

ZDB-FIG-200323-37

Publication

Gordon et al., 2019 - Fenestrae-associated protein Plvap regulates the rate of blood-borne proteins passage into the hypophysis

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Fig. 2

Neurohypophyseal vasculature is devoid of the BBB marker protein claudin 5. (A,B) Claudin 5 expression in hypophyseal vessels of 5 dpf larvae (A) or adult (B) was detected by whole-mount immunofluorescence staining using anti-claudin 5 antibody. Tg(kdrl:mCherry-caax) zebrafish. (C,D) Claudin 5 expression in brain vasculature was detected by whole-mount immunofluorescence staining using anti-claudin 5 antibody in 5 dpf larvae (C) or adult (D) Tg(kdrl:mCherry-caax) zebrafish. AMCtA, anterior (rostral) mesencephalic central artery; BCA, basal communicating artery; CrDI, cranial division of the internal carotid artery; HypA, hypophyseal artery; HypV, hypophyseal vein; PCS, posterior (caudal) communicating segment. Scale bars: 5 µm in A,C; 20 µm in B,D.

Expression Data

Gene:	mCherry
Antibody:	Ab1-cldn5
Fish:	y171Tg
Anatomical Terms:	anterior mesencephalic central artery blood vessel endothelium basal communicating artery blood vessel endothelium brain vasculature blood vessel endothelium hypophyseal artery blood vessel endothelium hypophyseal capillary blood vessel endothelium hypophyseal vein blood vessel endothelium internal carotid artery blood vessel endothelium posterior communicating artery blood vessel endothelium
Stage Range:	Day 5 to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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