FIGURE

Fig. 2

ID

ZDB-FIG-200227-2

Publication

Chen et al., 2020 - The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond-Blackfan anemia

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Rpl18-deficient embryos displayed physical abnormalities and anemia.

a–j Phenotypes of wild-type siblings and rpl18^−/− mutants (N = 7). At 24 hpf (a, b), aplasia of head region (dashed box) can be seen in mutant. At 30 hpf (c, d), pigmentation was delayed. At 36 hpf (e, f) and 2 dpf (g, h), a smaller head and edema (arrowhead) were present. At 3 dpf (i, j), edema (arrowhead) in heart and shorted tail extension was more apparent. Almost all embryos died at 4 dpf. k, lo-dianisidine staining showed depletion of erythroid cells in rpl18^−/− embryos compared with wild-type siblings (arrowheads pointed to the sites of weak o-dianisidine staining, N = 5). m, nrpl18 mRNA (100 pg/embryo) injected to embryos, staining of 3 dpf mutants with o-dianisidine showed a partial recovery (N = 3). All scale bars represent 250 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rpl18^{zf3219/zf3219} (TU)
Observed In:	head nucleate erythrocyte pericardium pigmentation whole organism
Stage Range:	Prim-5 to Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Death Dis.