FIGURE

Figure 5

ID

ZDB-FIG-200215-34

Publication

Li et al., 2020 - Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish

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Figure 5

<italic>celsr1a</italic> expression during development and as a function of age in adults.

(A) Strategy for GFP insertion at the celsr1a endogenous locus by homology directed repair. (B) Whole mount in situ analysis of celsr1a expression in early development (1dpf). (C) Expression of celsr1a in central nervous system (CNS), peripheral nervous system (PNS), and gut in the celsr1a^GFP/+ transgenic line. (D–J) Expression of celsr1a^GFP/+ transgene in larval, and juvenile zebrafish showing progressive restriction and localization to specific cell types and tissues. all, anterior lateral line; epi, epidermal cells; int, intestine; mph, metanephros; nm, neuromast; sl m, slow muscle; ot, otolith. (K–M) Restricted expression of celsr1a^GFP in adult tissues. (K) Expression of celsr1a^GFP in adult skin and neuromasts covering the lateral surface. (L–M) Expression of celsr1a is shown in anterior and posterior regions of the adult intestine.

Expression Data

Gene:	GFP
Fish:	celsr1a^mh202Tg
Anatomical Terms:	central nervous system epidermis eye gut integument intestinal epithelium intestine kidney lateral line neuromast peripheral nervous system pronephros slow muscle cell
Stage Range:	Prim-5 to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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