FIGURE

Fig. 7.

ID

ZDB-FIG-200205-12

Publication

Clark et al., 2019 - Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease

Other Figures

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Fig. 7.

Heat shock activates reporter expression. (A) Representative images showing increased 5XATF6RE:d2GFP expression in the spinal cord 8 h after heat shock compared to a control without heat shock. (B) Representative images and quantification of the lens (indicated by an arrow) revealed significantly higher levels of 5XATF6RE:d2GFP expression 2 days post-heat shock compared to a control without heat shock (P<0.0001). The dashed line outlines the eye. (C) Representative images and quantification of the head region (dashed line) revealed significantly higher levels of 5XATF6RE:d2GFP expression 12 h post-heat shock compared to a control without heat shock (P=0.0248). *P≤0.05; ****P≤0.0001; unpaired Student's t-test. All error bars are s.e.m. Scale bars: 0.1 mm (A,B); 1 mm (C).

Expression Data

Gene:	d2EGFP
Fish:	mw85Tg
Condition:	heat shock
Anatomical Terms:	head lens spinal cord
Stage Range:	Prim-15 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mw85Tg
Condition:	heat shock
Observed In:	head lens spinal cord
Stage Range:	Prim-15 to Protruding-mouth

Phenotype Detail

Acknowledgments

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