FIGURE

Fig 5

ID

ZDB-FIG-191230-639

Publication

Prill et al., 2019 - Myomesin is part of an integrity pathway that responds to sarcomere damage and disease

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Fig 5

Myomesin is absent in thick filament and titin mutant sarcomeres.

At 48hpf, myomesin is incorporated into the slow (perpendicular fibers) and fast (slanted fibers) muscle of wild-type siblings (A&E) while disorganized in smyd1b^tm123a (B&F), unc45b^sb60 (C&H) and titin2^tg287 (D&I) embryos. Increased magnification (40X) of muscle tissue demonstrates the sharp repeating striations of incorporated myomesin in wild-type siblings (E). Smyd1b^tm123a fast muscle (F; striations are visible in smyd1b^tm123a slow muscle, G), unc45b^sb60 (H) and titin2^tg287 (I) muscle lack myomesin striations even at 40X magnification.

Expression Data

Antibody:	Ab1-myom
Fish:	WT hel^tg287/tg287 smyd1b^{tm123a/tm123a} unc45b^sb60/sb60
Anatomical Terms:	fast muscle cell M band fast muscle cell sarcomere slow muscle cell slow muscle cell M band slow muscle cell sarcomere
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hel^tg287/tg287 smyd1b^{tm123a/tm123a} unc45b^sb60/sb60
Observed In:	fast muscle cell M band fast muscle cell sarcomere slow muscle cell M band slow muscle cell sarcomere striated muscle cell development
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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