FIGURE

Figure 4

ID

ZDB-FIG-191230-1638

Publication

Yang et al., 2019 - Nucleoporin 62-Like Protein is Required for the Development of Pharyngeal Arches through Regulation of Wnt/β-Catenin Signaling and Apoptotic Homeostasis in Zebrafish

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Figure 4

Loss of Nup62l induced extensive apoptosis in the impaired PA region. (A) Detection of apoptotic cells in PA of nup62l-mutants with TUNEL assays at indicated stages. PA, pharyngeal arches. (B) Strongly elevated caspase 3 activity in nup62l-mutants at 60 hpf in comparison with that in WT siblings. The data expressed as Mean ± SD were representatives of three independent experiments, each done with three samples of 15 zebrafish. ** p < 0.01. (C) WISH assays showing lateral views of the expression of caspase 3a and caspase 3b genes in WT or nup62l-mutants at 48 hpf, 60 hpf or 72 hpf.

Expression Data

Genes:	casp3a casp3b
Fish:	AB nup62l^{zf3224/zf3224} (AB)
Anatomical Terms:	eye optic tectum pharyngeal arch
Stage Range:	Long-pec to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nup62l^{zf3224/zf3224} (AB)
Observed In:	eye eye apoptotic process optic tectum optic tectum apoptotic process pharyngeal arch pharyngeal arch apoptotic process
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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