FIGURE

Figure 5

ID

ZDB-FIG-191230-1014

Publication

Griffin et al., 2019 - Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome

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Figure 5

Dose response evaluation of 5HT2BR agonists in scn1lab mutant zebrafish. 5HT2BR agonists were tested for efficacy in reducing the high-speed seizure-like behaviour in 5 dpf scn1lab mutant zebrafish. Graphs show the change in mean velocity over three concentrations of (a) methylergonovine, (b) 6-APB, (c) norfenfluamine, (d) BW-723C86, (e) RO-60-0175, (f) TL-99, (g) m-CPP and (h) CP-809, 101. Larvae locomotion was recorded for 10 min after an exposure of 30 min (blue bars) and 90 min (yellow bars). Each bar represents the mean change in velocity ± SEM from three independent experiments (six individual larva per experiment). The threshold for a decrease in velocity is ≥40% (red line). Representative tracking plots of a 10 min recording are shown for six individual 5 dpf scn1lab zebrafish at baseline, and following 30 min and 90 min exposure of 100 µM of each compound.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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