FIGURE

Fig. 2

ID

ZDB-FIG-190925-20

Publication

Gath et al., 2019 - Zebrafish mab21l2 mutants possess severe defects in optic cup morphogenesis, lens and cornea development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

mab21l2^−/− mutants possess delays in lens morphogenesis and lens growth, and do not properly express markers of mature lens cell types. A‐N: Transverse sections of wild‐type (A‐G) and mab21l2^−/− mutant (H‐N) embryos showing lens development over time. Compared with wild‐type, mab21l2^−/− mutants do not show induction of lens morphogenesis at 18SS (H); instead, comparable development is not detected until 22SS (I). Lenses remain smaller at 28 hpf (K), 36 hpf (L), 48 hpf (M), and 5 dpf (N). Note pyknotic nuclei in 28 hpf mutant (K, arrowhead). O‐Z: Whole‐mount in situ hybridizations of 48 hpf wild‐type (O‐T) and mab21l2^−/− (U‐Z) embryos. Note apparently reduced tgfβ3 (U), prox1 (X), and celf1 (Y) in mab21l2^−/− mutants, compared with wild‐type (O,R,S, respectively). Note also that mab21l2^−/− mutants lack detectable pitx3 (V), foxe3 (w), and cryaa(Z) expression. Dorsal is up in all panels. Scale bars = 50 μm

Expression Data

Genes:	celf1 foxe3 pitx3 prox1a tgfb3
Fish:	AB mab21l2^au10/au10 (AB)
Anatomical Terms:	lens epithelium lens fiber cell
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mab21l2^au10/au10 (AB)
Observed In:	lens lens epithelium lens fiber cell lens morphogenesis in camera-type eye
Stage Range:	14-19 somites to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dev. Dyn.