FIGURE

Fig. 5

ID

ZDB-FIG-190826-10

Publication

Kague et al., 2019 - Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish

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Fig. 5

Scxa is is required for rib mineralization and its patterning. AR staining for fish from a scxa^+/− incross at the indicated juvenile stages. A) At SL 5.8 mm, increased differential interference contrast (DIC) shows that the junction region between muscle and rib (yellow arrows) is already abnormal (AA′). B) At SL 6.5 mm, the first anterior ribs (r5 and r6) are lacking (asterisks in B′, compared with B). C) A severe lack of mineralized ribs (black asterisks) and mineralized rib fragments (white arrowhead) is seen at SL 10.5 mm (C′, compared with C). D) In another mutant (D), some ribs are missing (asterisks in D), whereas others are highly fractured and healed (r5–r9 magnified and marked by red arrowheads in D′). Note that r4 is formed normally (arrows in B–D). All scale bars, 100 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	scxa^kg170/kg170 (AB)
Observed In:	rib rib bone mineralization rib bone morphogenesis rib of vertebra 4 rib of vertebra 5 rib of vertebra 6 skeletal system
Stage Range:	Days 14-20 to Days 30-44

Phenotype Detail

Acknowledgments

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