FIGURE

Fig. 4

ID

ZDB-FIG-190820-74

Publication

Li et al., 2019 - Liver-specific androgen receptor knockout attenuates early liver tumor development in zebrafish

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Fig. 4

Effects of liver-specific ar knockout on male kras zebrafish. (A) Kaplan-Meier survival curves of male kras and kras/L-ARKO zebrafish during 14-day Dox treatment. (B,C) Representative images of the gross observations (upper) and liver histology images (lower) from WT, L-ARKO, kras and kras/L-ARKO zebrafish after Dox induction for one week (B) or two week (C). Livers are outlined by a dashed line. (D,E) Quantitative analyses of histological phenotypes of liver sections from the 1-wpi (D) and 2-wpi (E) samples. HCA, hepatocellular adenoma; HCC, hepatocellular carcinoma. Statistical significance between the kras and kras/L-ARKO groups for the incidence of different tumor types: *p < 0.05; ****p < 0.0001; ns, no significant difference.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gz32Tg gz32Tg; gz39Tg
Condition:	chemical treatment by environment: doxycycline
Observed In:	liver liver hepatocellular adenoma liver hepatocellular carcinoma male organism
Stage:	Adult

Phenotype Detail

Acknowledgments

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