ZFIN Image: Li et al., 2019, Fig. 4

Image

Figure Caption

Fig. 4

Effects of liver-specific ar knockout on male kras zebrafish. (A) Kaplan-Meier survival curves of male kras and kras/L-ARKO zebrafish during 14-day Dox treatment. (B,C) Representative images of the gross observations (upper) and liver histology images (lower) from WT, L-ARKO, kras and kras/L-ARKO zebrafish after Dox induction for one week (B) or two week (C). Livers are outlined by a dashed line. (D,E) Quantitative analyses of histological phenotypes of liver sections from the 1-wpi (D) and 2-wpi (E) samples. HCA, hepatocellular adenoma; HCC, hepatocellular carcinoma. Statistical significance between the kras and kras/L-ARKO groups for the incidence of different tumor types: *p < 0.05; ****p < 0.0001; ns, no significant difference.

Figure Data

Phenotype details

Acknowledgments

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