FIGURE

Fig. 9

ID

ZDB-FIG-190819-7

Publication

Su et al., 2019 - A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish

Other Figures

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Fig. 9

Immunoreactive score of the phosphatase and tensin homologues deleted on chromosome 10 (PTEN). Immunostaining reveals that PTEN shows no difference between control and AURKA transgenic zebrafish. (A) Representative images of immunohistochemistry (IHC) staining for PTEN in control, AURKA(WT), and AURKA(V352I) at 3, 5, 7, 9, and 11 months; (B) Selected enlarged images show the PTEN signals from AURKA(WT)—7 M and AURKA(V352I)—7 M; (C) Statistical analysis of PTEN immunostaining IRS score at 3, 5, 7, 9 and 11 months. IRS score of control fish (Tg(fabp10a:EGFP-mCherry) abbreviated as mC, AURKA(WT) and AURKA(V352I) is shown in red (3 M), orange (5 M), green (7 M), purple (9 M), and blue (11 M). Statistical analysis of results was performed using a two-tailed Student’s t-test. The error bar means standard deviation.

Expression Data

Antibody:	Ab1-ptena
Fish:	nn1000Tg nn1010Tg nn1011Tg
Anatomical Term:	liver
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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