FIGURE

Fig 6

ID

ZDB-FIG-190723-527

Publication

Samarut et al., 2019 - Individual knock out of glycine receptor alpha subunits identifies a specific requirement of glra1 for motor function in zebrafish

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Fig 6

Hic mutants display motor coordination dysfunction.

A, Touch-evoked escape response of hitch mutants versus their siblings at 7 dpf show a dysfunction of motor coordination of hic-/- larvae. Indeed, hic-/- larvae are not able to bend their tail in a coordinated manner in order to initiate an escape swimming response (see S1 and S2 Movies for full recordings). B, Hic-/- larvae at 7 dpf show a reduction of the trunk size as well as defects of the notochord and a change in birefringence of trunk muscles. C, Measurement of the trunk size at different age shows that the reduction in trunk length starts at 3 dpf and aggravates at 7 dpf presumably due to the motor dysfunction.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	glra1^{udm105/udm105}
Observed In:	myotome notochord thigmotaxis trunk
Stage Range:	Protruding-mouth to Days 7-13

Phenotype Detail

Acknowledgments

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