FIGURE

Fig. 2

ID

ZDB-FIG-190723-2546

Publication

Martorano et al., 2019 - The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria

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Fig. 2

Analysis of mitochondrial ultrastructure and volume in mpv17^−/− and wild-type liver at 6 dpf. (A) TEM analysis of wild-type (a) and mpv17^−/− liver hepatocytes (b) (n=3). Scale bars: 2 µM. (B) Confocal images of double Tg(COXVIII-mls:EGFP); Tg(lfabp:dsRed) mpv17^+/? and mpv17^−/− siblings at 6 dpf (n=13) and 12 dpf (n=8). Scale bars: 50 µm. (C) Relative quantification of integrated density. Statistical analyses were performed using two-tailed Student's t-test. Statistical significance was evaluated by setting a confidence interval of 95%; data are mean±s.e.m. ns, not significant. Experiments were performed in biological replicates.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mpv17^a9/a9 mpv17^a9/a9; gz15Tg; ia301Tg
Observed In:	hepatocyte liver mitochondrial crista liver mitochondrion
Stage Range:	Day 6 to Days 7-13

Phenotype Detail

Acknowledgments

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