FIGURE

Figure 7

ID

ZDB-FIG-190723-1720

Publication

Ouyang et al., 2019 - CPSF1 mutations are associated with early-onset high myopia and involved in retinal ganglion cell axon projection

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Figure 7

RGC axon projection to the tectum was abnormal in cpsf1 morphants. (A) RGC axon projection in zebrafish at 5 dpf. Left: RGC axon projection in std MO-injected zebrafish, right: RGC axon projection in cpsf1 morphants. Data showed that cpsf1 morphants showed less innervation to the tectum than std MO-injected zebrafish. (B) Histogram of the percentage of larvae with the phenotype of reduced innervation of the tectum. The area of the tectum with DiI tracing was 18570.60 ± 3969.32 μm² (n = 63) in std MO-injected zebrafish, and 8895.07 ± 3756.63 μm² (n = 65) in cpsf1 MO-injected zebrafish. Approximately 84.62% of cpsf1 morphants displayed reduced area of the tectum, but only 7.94% of std MO-injected zebrafish had this phenotype (P = 3.59 × 10⁻¹⁸, Chi-square test). The number of zebrafish injected in each group is indicated under each column.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO5-cpsf1
Knockdown Reagent:	MO5-cpsf1
Observed In:	optic tectum optic tectum innervation retinal ganglion cell neuron projection retinal ganglion cell axon guidance
Stage:	Day 5

Phenotype Detail

Acknowledgments

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